Clinical Trials
Volunteering Your Body For Cancer Research

Clinical Trials | How? | What? | Why?

Where?

Where are the clinical trials?
Which ones are available in my area?

CURRENT CLINICAL TRIALS

VERITAS-- select Breast Cancer from the box on right and you will be taken to a page of info and further links on clinical trials for Breast Cancer -- such as ongoing clinical trials that match your medical and geographical criteria, treatment options and information about investigational and current drugs as well as a newsletter and Personalized Trial Notification.

NEWEST TRIALS

"Hundreds of patients are being sought to take part in three clinical trials to study the experimental anti-VEGF antibody (Avastin) in combination with chemotherapy on advanced breast and colorectal cancers.......the angiogenesis inhibitor is an anti-vascular endothelial growth factor (anti-VEGF) antibody, meaning it targets a protein that promotes new blood vessel formation, called angiogensis."

The above referenced study is for patients whose breast cancer has progressed after either one or two chemotherapy regimens and will be randomly assigned to this two-arm study, which tests Xeloda with and without the antibody (Avastin). See:
http://cancer.mednet.ucla.edu/newsmedia/news/pr053001.html

Dr. Dennis Slamon, director of Clinical and Translational Research at UCLA Jonsson Cancer Center said, "the results were impressive....this is a new and exciting therapy and we're getting real results in early studies."

AVASTIN (Bevacizumab) is the same drug being used in the Phase II NCI clinical trial with NEW ibc patients, not those who have failed one or more chemos already--AND it is not randomized so ALL participating patients will receive the Avastin, along with Adriamycin & Taxotere at the start of treatment.

Phase III Randomized Study of Bevacizumab With Capecitabine Versus Capecitabine Alone in Women With Previously Treated Metastatic Breast Cancer (Summary Last Modified 03/2001).

Patient Abstract Rationale: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. It is not yet known if chemotherapy is more effective with or without monoclonal antibody in treating metastatic breast cancer.

Purpose: Randomized phase III trial to study the effectiveness of capecitabine with or without bevacizumab in treating women who have metastatic breast cancer.

Treatment: Patients will be randomly assigned to one of two groups. Patients in group one will receive capecitabine by mouth once a day for 2 weeks. Patients in group two will receive capecitabine by mouth once a day for 2 weeks plus an infusion of bevacizumab on day 1. Treatment in both groups may be repeated every 3 weeks for up to 35 courses. Quality of life will be assessed periodically. Patients will receive follow-up evaluations every 4 months after completion of the study.

To obtain more details related to trial eligibility and the treatment plan, please see the Health Professional abstract of this clinical trial at the National Cancer Institute website.

State By State Listing

ACURIAN lists clinical trials by state and sends them to you weekly. You will have to investigate each one as most are headed: "First Line Treatment of Postmenopausal Women with Metastatic Breast Cancer: " The listing will tell you whether it is randomized, open-label or other descriptors and eligibility requirements. A very good resource.

NCI -- The National Cancer Trials website with more information about clinical trials. Very Comprehensive.

Other

CTSU -- Cancer Trials Support Unit -- a pilot project for Phase III clinical trials for doctors and patients.

CTCA -- Clinical Trials -- Cancer Treatment Centers of America

Clinical Trials currently active through CTCA:

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